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Vioxx, approved in June 1999, is a non-steroidal, anti-inflammatory drug, and is in a class of drugs commonly referred to as a "Cox-2 Inhibitors." Cox-2 Inhibitors include Vioxx, Celebrex and Bextra. Vioxx comes in liquid or pill form and is manufactured by Merck & Co. Vioxx was prescribed to relieve the symptoms of osteoarthritis. It can also be used to treat acute pain in adults such as those patients who experience severe pain associated with menstruation. Vioxx works by blocking COX-2 enzymes in the body that trigger pain and inflammation.